منابع مشابه
Cell-substrate adhesion during Trypanosoma cruzi differentiation
The transformation of Trypanosoma cruzi epimastigotes to the mammal infective metacyclic trypomastigotes (metacyclogenesis) can be performed in vitro under chemically defined conditions. Under these conditions, differentiating epimastigotes adhere to a surface before their transformation into metacyclic trypomastigotes. Scanning and transmission electron microscopy of adhered and non-adhered pa...
متن کاملCell-adhesion and substrate-adhesion molecules: their instructive roles in neural crest cell migration.
The individualization of crest cells from the neural folds and neural tube involves distinct mechanisms affecting both the tissue shape and the cell environment. Though these mechanisms are not fully understood at the molecular level, the analysis of the distribution of several molecules reported to promote intercellular contacts indicates a correlation between cell detachment from the neurepit...
متن کاملThe interplay of cell-cell and cell-substrate adhesion in collective cell migration.
Collective cell migration often involves notable cell-cell and cell-substrate adhesions and highly coordinated motion of touching cells. We focus on the interplay between cell-substrate adhesion and cell-cell adhesion. We show that the loss of cell-surface contact does not significantly alter the dynamic pattern of protrusions and retractions of fast migrating amoeboid cells (Dictyostelium disc...
متن کاملCell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression.
Integrins are transmembrane receptors involved in interactions between cells and extracellular matrix proteins. Here we show that cell adhesion regulates insulin receptor substrate-1 (IRS-1) mRNA synthesis. When fibroblasts are held in suspension, lower levels of IRS-1 mRNA, but not of IRS-2 mRNA, are detected, and this effect is due to the negative regulation of IRS-1 transcription rather than...
متن کاملA GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts
Cell-substrate adhesion is crucial at various stages of development and for the maintenance of normal tissues. Little is known about the regulation of these adhesive interactions. To investigate the role of GTPases in the control of cell morphology and cell-substrate adhesion we have injected guanine nucleotide analogs into Xenopus XTC fibroblasts. Injection of GTP gamma S inhibited ruffling an...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 1986
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.86.1.9